Familial polyposis coli
Familial polyposis coli is known as familial adenomatous polyposis. This is a hereditarily inherited ailment. Numerous adenomas become in the epithelium of the colon. They start as benevolent polyps however tend to wind up dangerous and lead to colon tumor if not treated appropriately. There are three sorts: familial adenomatous polyposis , lessened FAP likewise called inherited level adenoma disorder and autosomal latent FAP additionally called MYH related polyposis.
Familial adenomatous polyposis is the aftereffect of a hereditary change and is the most widely recognized adenomatous polyposis disorder.
FAP is quiet a rare condition and affects 1 in 10,000 people.
Genetic condition and mutation of the adenomatous polyposis coli or APC gene present in chromosome 5. The APC
gene is a tumor suppressor located on band 5q21 and regulates a protein called B-catenin which is responsible
for cell growth and destruction. When APC is faulty, then the cells are not controlled and manifest as polyps
and can be cancerous.
Inherited from parents
Unexplained mutations which have erupted not due to inheritance
- Iron deficiency anemia
- Abdominal pain
- Rectal bleeding
- Diarrhea
- Weight loss
Flexible sigmoidoscopy or colonoscopy: This procedure helps in examining the lower part of the bowel via the rectum. Air is blown into the tube which is inserted into the intestine to look for polyps.
Endoscopic colonoscopy: This is done for patients with colonic symptoms to examine the digestive tract.
Genetic testing: A family history for the disease is studied and a genetic testing is done to confirm and clarify the diagnosis.
Patients with familial polyposis coli will require total proctocolectomy as this condition has a pre-malignant potential.